Title : Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.

Pub. Date : 2015 Nov

PMID : 26206502






3 Functional Relationships(s)
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1 Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs. Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens
2 Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs. Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens
3 Because the degradation of Glc3Man9GlcNAc2-PP-Dol is greatly inhibited in the presence of an N-glycosylation acceptor peptide that is recognized by the oligosaccharyltransferase (OST), the OST-mediated hydrolysis of DLO is the most likely mechanism responsible for the production of a large fraction of the cytosolic fOSs. Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens