Title : KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.

Pub. Date : 2015 Aug 1

PMID : 26205490






2 Functional Relationships(s)
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1 Furthermore, sustained activation of thiol redox networks by KEAP1-NRF2 induces a reductive stress, by decreasing the lifetime of necessary oxidative post-translational modifications required for normal metabolism or cell signalling. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens
2 Recent studies indicate that the modification of protein thiols plays an important role in the regulation of both the KEAP1-NRF2 and autophagy pathways. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens