Title : Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis.

Pub. Date : 2015 Dec

PMID : 26202867






4 Functional Relationships(s)
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1 Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis. Isoniazid NFE2 like bZIP transcription factor 2 Homo sapiens
2 Isoniazid increased cytosolic Nrf2 protein level while decreased nuclear Nrf2 protein level. Isoniazid NFE2 like bZIP transcription factor 2 Homo sapiens
3 Isoniazid increased cytosolic Nrf2 protein level while decreased nuclear Nrf2 protein level. Isoniazid NFE2 like bZIP transcription factor 2 Homo sapiens
4 Results suggest that Isoniazid induces apoptosis through oxidative stress and also prevents Nrf2 translocation into the nucleus by reducing ERK1 phosphorylation thus preventing cytoprotective effect. Isoniazid NFE2 like bZIP transcription factor 2 Homo sapiens