Pub. Date : 2015 Oct
PMID : 26202455
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation. | Quercetin | sirtuin 1 | Homo sapiens |
| 2 | This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals. | Quercetin | sirtuin 1 | Homo sapiens |
| 3 | This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals. | Quercetin | sirtuin 1 | Homo sapiens |
| 4 | We found that quercetin pretreatment increased SIRT1 mRNA expression. | Quercetin | sirtuin 1 | Homo sapiens |
| 5 | In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4. | Quercetin | sirtuin 1 | Homo sapiens |
| 6 | However, silencing SIRT1 and AMPK diminished the protective function of quercetin against oxidative injuries. | Quercetin | sirtuin 1 | Homo sapiens |
| 7 | Quercetin suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway. | Quercetin | sirtuin 1 | Homo sapiens |