Title : Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ.

Pub. Date : 2015 Nov 15

PMID : 26187065






7 Functional Relationships(s)
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1 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
2 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
3 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
4 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
5 Inhibition by DHT persists when upstream Smad and Runx REs in the IGF-I gene promoter are mutated. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
6 Still, DHT suppresses TGF-beta induced IGF-I promoter activity, but not its effects on DNA or collagen synthesis. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
7 Thus DHT suppresses the PGE2 and TGF-beta induced IGF-I gene promoter and differentiates other aspects of TGF-beta activity in osteoblasts. Dihydrotestosterone insulin like growth factor 1 Homo sapiens