Pub. Date : 2015
PMID : 26181325
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We observed that combinations of lapatinib plus AKTi were synergistic in HER2(+)/PIK3CA(mut) cell lines but not in HER2(+)/PIK3CA(wt) cell lines. | Lapatinib | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Homo sapiens |
| 2 | This revealed that p-S6RP levels were less well attenuated by lapatinib in HER2(+)/PIK3CA(mut) cells compared to HER2(+)/PIK3CAwt cells and that lapatinib + AKTi reduced p-S6RP levels to those achieved in HER2(+)/PIK3CA(wt) cells with lapatinib alone. | Lapatinib | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Homo sapiens |
| 3 | We also found that that compensatory up-regulation of p-HER3 and p-HER2 is blunted in PIK3CA(mut) cells following lapatinib + AKTi treatment. | Lapatinib | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Homo sapiens |
| 4 | We used a nonlinear ordinary differential equation model to support the idea that PIK3CA mutations act as downstream activators of AKT that blunt lapatinib inhibition of downstream AKT signaling and that the effects of PIK3CA mutations can be countered by combining lapatinib with an AKTi. | Lapatinib | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Homo sapiens |