Title : Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

Pub. Date : 2015 Aug 13

PMID : 26177091






1 Functional Relationships(s)
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1 Homologation to the corresponding diene analogues yielded a mixture of Z,E and E,E isomers; substitution of the indoline nitrogen with an N-benzyl group resulted in increased binding to alpha-syn and reasonable selectivity for alpha-syn versus Abeta and tau. Nitrogen amyloid beta precursor protein Homo sapiens