Title : Heterogeneity of subordination of the IL-18/IFN-γ axis to caspase-1 among patients with Crohn's disease.

Pub. Date : 2015 Oct

PMID : 26168332






1 Functional Relationships(s)
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1 Inhibition of caspase-1 activation using the specific inhibitor YVAD identified a homogenous non responder group featuring a caspase-1-independent IL-18/IFN-gamma response, and a heterogenous responder group, in which both IL-18 and IFN-gamma responses were caspase-1-dependent, with a 40-70% range of inhibition by YVAD. YVAD interferon gamma Homo sapiens