Title : Stimulation of Wnt/β-Catenin Signaling to Improve Bone Development by Naringin via Interacting with AMPK and Akt.

Pub. Date : 2015

PMID : 26159568






5 Functional Relationships(s)
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1 RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors. naringin catenin beta 1 Rattus norvegicus
2 RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors. naringin catenin beta 1 Rattus norvegicus
3 The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK. naringin catenin beta 1 Rattus norvegicus
4 The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK. naringin catenin beta 1 Rattus norvegicus
5 The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK. naringin catenin beta 1 Rattus norvegicus