Title : Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise.

Pub. Date : 2015 Jul

PMID : 26156967






4 Functional Relationships(s)
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1 An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. Fatty Acids acetyl-Coenzyme A carboxylase beta Mus musculus
2 An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. Fatty Acids acetyl-Coenzyme A carboxylase beta Mus musculus
3 In resting muscle the activation of AMPK with AICAR leads to increased phosphorylation of ACC (S79 on ACC1 and S221 on ACC2), which reduces ACC activity and malonyl-CoA; effects associated with increased fatty acid oxidation. Fatty Acids acetyl-Coenzyme A carboxylase beta Mus musculus
4 We find that surprisingly, ACC2-KI mice had normal exercise capacity and whole-body fatty acid oxidation during treadmill running despite elevated muscle ACC2 activity and malonyl-CoA. Fatty Acids acetyl-Coenzyme A carboxylase beta Mus musculus