Pub. Date : 2015 Jul
PMID : 26156967
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. | Fatty Acids | acetyl-Coenzyme A carboxylase beta | Mus musculus |
| 2 | An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. | Fatty Acids | acetyl-Coenzyme A carboxylase beta | Mus musculus |
| 3 | In resting muscle the activation of AMPK with AICAR leads to increased phosphorylation of ACC (S79 on ACC1 and S221 on ACC2), which reduces ACC activity and malonyl-CoA; effects associated with increased fatty acid oxidation. | Fatty Acids | acetyl-Coenzyme A carboxylase beta | Mus musculus |
| 4 | We find that surprisingly, ACC2-KI mice had normal exercise capacity and whole-body fatty acid oxidation during treadmill running despite elevated muscle ACC2 activity and malonyl-CoA. | Fatty Acids | acetyl-Coenzyme A carboxylase beta | Mus musculus |