PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26156967-2 2015 An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. Fatty Acids 26-36 acetyl-Coenzyme A carboxylase beta Mus musculus 119-123 26156967-2 2015 An important regulator of fatty acid oxidation is acetyl-CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. Fatty Acids 26-36 acetyl-Coenzyme A carboxylase beta Mus musculus 130-134 26156967-5 2015 In resting muscle the activation of AMPK with AICAR leads to increased phosphorylation of ACC (S79 on ACC1 and S221 on ACC2), which reduces ACC activity and malonyl-CoA; effects associated with increased fatty acid oxidation. Fatty Acids 204-214 acetyl-Coenzyme A carboxylase beta Mus musculus 119-123 26156967-8 2015 We find that surprisingly, ACC2-KI mice had normal exercise capacity and whole-body fatty acid oxidation during treadmill running despite elevated muscle ACC2 activity and malonyl-CoA. Fatty Acids 84-94 acetyl-Coenzyme A carboxylase beta Mus musculus 27-31