Title : Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.

Pub. Date : 2015 Nov

PMID : 26153065






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Buprenorphine, a maintenance drug for heroin addicts, exerts its pharmacological function via kappa- (KOP), mu-opioid (MOP) and nociceptin/opioid receptor-like 1 (NOP) receptors. Buprenorphine serine peptidase inhibitor, Kunitz type 2 Homo sapiens
2 Buprenorphine, when applied acutely, inhibited AC activity to ~90% in cells expressing KOP+MOP+NOP receptors. Buprenorphine serine peptidase inhibitor, Kunitz type 2 Homo sapiens
3 Chronic exposure to buprenorphine induced concentration-dependent AC superactivation in cells expressing KOP+NOP receptors, and the level of this superactivation was even higher in KOP+MOP+NOP-expressing cells. Buprenorphine serine peptidase inhibitor, Kunitz type 2 Homo sapiens
4 Chronic exposure to buprenorphine induced concentration-dependent AC superactivation in cells expressing KOP+NOP receptors, and the level of this superactivation was even higher in KOP+MOP+NOP-expressing cells. Buprenorphine serine peptidase inhibitor, Kunitz type 2 Homo sapiens