| Protein Name | serine peptidase inhibitor, Kunitz type 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10653 |
| Gene Symbol | SPINT2 |
| UniProt | O43291 (SPIT2_HUMAN), A0A140VJV6 (A0A140VJV6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
44
Total Number of Articles : 42 |
Description |
serine peptidase inhibitor, Kunitz type 2 |
| Gene Summary |
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
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