Pub. Date : 2015 Jul
PMID : 26150586
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel GnRH antagonists, such as degarelix, and cytochrome P450 17 (CYP17) enzyme inhibitors, such as ketoconazole, achieve castrate-equivalent serum testosterone levels much faster than traditional GnRH agonists without the need for coadministration of antiandrogens. | Ketoconazole | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Novel GnRH antagonists, such as degarelix, and cytochrome P450 17 (CYP17) enzyme inhibitors, such as ketoconazole, achieve castrate-equivalent serum testosterone levels much faster than traditional GnRH agonists without the need for coadministration of antiandrogens. | Ketoconazole | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | In the setting of symptomatic hormone-naive metastatic prostate cancer, the authors suggest clinical trials using abiraterone, orteronel, and other newer agents that target the CYP17 axis (eg, ketoconazole) for fine-tuning the emergent medical castration methods and avoiding the dangers from the flare phenomenon. | Ketoconazole | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |