Pub. Date : 2015 Sep
PMID : 26137927
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Tyrosinase was modified by reactive-oxygen-species (ROS). | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 2 | METHODS: Tyrosinase was modified by reactive-oxygen-species (ROS). | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 3 | Binding characteristics of antibodies in vitiligo patients (n=25) with varying disease duration (DD) and disease severity were screened against ROS-modified tyrosinase (ROS-tyrosinase) by immunoassays and their results were compared with healthy controls (n=23). | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 4 | RESULTS: The ROS caused extensive alterations in conformation and function of tyrosinase. | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 5 | Interestingly, not only was there an increased number of subjects positive for anti-ROS-tyrosinase-IgGs, but also the levels of these IgGs were significantly higher among vitiligo patients, whose DD were >=10 years as compared to patients with short DD (<10 years). | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 6 | In addition, a significant correlation was observed between the levels of anti-ROS-tyrosinase-IgGs and the patients" ages or with disease severity. | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 7 | Experimentally induced anti-ROS-tyrosinase-IgGs show reactivity with tyrosinase from vitiligo patients. | Reactive Oxygen Species | tyrosinase | Homo sapiens |
| 8 | Experimentally induced anti-ROS-tyrosinase-IgGs show reactivity with tyrosinase from vitiligo patients. | Reactive Oxygen Species | tyrosinase | Homo sapiens |