Pub. Date : 2015
PMID : 26137220
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By deleting the cytosolic isoform of IDH (IDH1), the enhanced contribution of glutamine to the lipogenic acetyl-CoA pool during PDHA1 suppression was eliminated, and growth was modestly suppressed. | Acetyl Coenzyme A | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | By deleting the cytosolic isoform of IDH (IDH1), the enhanced contribution of glutamine to the lipogenic acetyl-CoA pool during PDHA1 suppression was eliminated, and growth was modestly suppressed. | Acetyl Coenzyme A | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | We also identify the compensatory mechanisms that are activated under PDH deficiency, namely scavenging of extracellular lipids and lipogenic acetyl-CoA production from reductive glutamine metabolism through IDH1. | Acetyl Coenzyme A | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |