PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26137220-10 2015 By deleting the cytosolic isoform of IDH (IDH1), the enhanced contribution of glutamine to the lipogenic acetyl-CoA pool during PDHA1 suppression was eliminated, and growth was modestly suppressed. Acetyl Coenzyme A 105-115 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 37-40 26137220-10 2015 By deleting the cytosolic isoform of IDH (IDH1), the enhanced contribution of glutamine to the lipogenic acetyl-CoA pool during PDHA1 suppression was eliminated, and growth was modestly suppressed. Acetyl Coenzyme A 105-115 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-46 26137220-13 2015 We also identify the compensatory mechanisms that are activated under PDH deficiency, namely scavenging of extracellular lipids and lipogenic acetyl-CoA production from reductive glutamine metabolism through IDH1. Acetyl Coenzyme A 142-152 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 208-212