Title : Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways.

Pub. Date : 2015 Jun

PMID : 26136978






1 Functional Relationships(s)
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1 With regard to the intracellular signaling in the TGF-beta-stimulated VEGF synthesis, resveratrol and SRT1720 significantly attenuated the phosphorylation of p44/p42 MAP kinase and SAPK/JNK stimulated by TGF-beta; however, the TGF-beta-induced phosphorylation of Smad2 and p38 MAP kinase was hardly affected by resveratrol or SRT1720. Resveratrol SMAD family member 2 Mus musculus