Pub. Date : 2015 Aug 14
PMID : 26134561
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | In this study, DHA stimulated glucose uptake in the skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | In this study, DHA stimulated glucose uptake in the skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | GPR120-mediated increase in intracellular Ca(2+) was critical for DHA-mediated AMPK phosphorylation and glucose uptake. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | In addition, DHA stimulated GLUT4 translocation AMPK-dependently. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | Inhibition of AMPK and Ca(2+)/calmodulin-dependent protein kinase kinase blocked DHA-induced glucose uptake. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 7 | DHA increased AMPK phosphorylation, glucose uptake, and intracellular Ca(2+) concentration in primary cultured myoblasts. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 8 | Taken together, these results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles. | Docosahexaenoic Acids | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |