Pub. Date : 2015 Sep 15
PMID : 26125441
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Critical role of Wnt/beta-catenin signaling in driving epithelial ovarian cancer platinum resistance. | Platinum | catenin beta 1 | Homo sapiens |
| 2 | Taken together, our data is the first report providing evidence that the Wnt/beta-catenin signaling pathway maintains stem-like properties and drug resistance of primary HGSOC PDX derived platinum resistant models, and therapeutic targeting of this pathway with iCG-001/PRI-724, which has been shown to be well tolerated in Phase I trials, may be an effective treatment option. | Platinum | catenin beta 1 | Homo sapiens |