Title : Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.

Pub. Date : 2015 Dec

PMID : 26119076






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. epiberberine fatty acid synthase Homo sapiens
2 In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. epiberberine fatty acid synthase Homo sapiens
3 These results indicate that the anti-adipogenic mechanism of epiberberine is associated with inhibition of phosphorylation of Raf/MEK1/ERK1/2 and AMPKalpha/Akt, followed by downregulation of the major transcription factors of adipogenesis, such as PPAR-gamma, C/EBP-alpha, and SREBP-1, and FAS. epiberberine fatty acid synthase Homo sapiens