Title : The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells.

Pub. Date : 2015 Sep 5

PMID : 26111761






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression. farrerol kelch-like ECH-associated protein 1 Mus musculus
2 Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression. farrerol kelch-like ECH-associated protein 1 Mus musculus
3 It is hence likely that farrerol inactivated KEAP-1 or activated the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduced the intracellular production of reactive oxygen species via the induction of HO-1 expression. farrerol kelch-like ECH-associated protein 1 Mus musculus
4 It is hence likely that farrerol inactivated KEAP-1 or activated the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduced the intracellular production of reactive oxygen species via the induction of HO-1 expression. farrerol kelch-like ECH-associated protein 1 Mus musculus