Pub. Date : 2015 Jun
PMID : 26111693
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The expressions of caspase-3 and Bax protein were significantly increased (P<0.05) and Bcl-2 protein expression was decreased (P<0.05) with a lowered Bcl-2/Bax ratio in AGEs-treated fibroblasts (P<0.05), and such changes were significantly reversed by metformin treatment (P<0.05). | Metformin | BCL2 apoptosis regulator | Homo sapiens |
2 | CONCLUSION: Metformin can antagonize AGEs-induced apoptosis in human dermal fibroblasts by regulating the expressions of caspase-3, Bax and Bcl-2. | Metformin | BCL2 apoptosis regulator | Homo sapiens |