Title : Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration.

Pub. Date : 2015 Sep

PMID : 26102179






2 Functional Relationships(s)
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1 The absorption difference of arctigenin in the normal and diabetic rats could be eliminated by the pretreatment of classic P-gp inhibitor verapamil, suggesting that P-gp might be the key factor causing the absorption enhancement of arctigenin in diabetic rats. Verapamil ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 The absorption difference of arctigenin in the normal and diabetic rats could be eliminated by the pretreatment of classic P-gp inhibitor verapamil, suggesting that P-gp might be the key factor causing the absorption enhancement of arctigenin in diabetic rats. Verapamil ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus