Title : The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.

Pub. Date : 2015 Aug

PMID : 26099967






1 Functional Relationships(s)
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1 However, bortezomib induces phosphorylation of IkappaB and activation of NF-kappaB in MM cells, while ibrutinib inhibits the IkappaB/NF-kappaB axis, suggesting antagonistic signaling. ibrutinib nuclear factor kappa B subunit 1 Homo sapiens