Title : [Study of the effect of etoposide on the fluidity of dipalmitoylphosphatidylcholine liposome by differential scanning calorimetry and Raman spectroscopy].

Pub. Date : 1989

PMID : 2609973






3 Functional Relationships(s)
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1 The interaction of the anticancer drug, etoposide (VP16-213), with DPPC bilayer vesicles was investigated by DSC and Laser Raman techniques. 1,2-Dipalmitoylphosphatidylcholine host cell factor C1 Homo sapiens
2 The results present the fact that the incorporation of VP16-213 into aqueous dispersion of DPPC not only shifted the temperatures of phase transition towards higher value but also broadened the half-height width. 1,2-Dipalmitoylphosphatidylcholine host cell factor C1 Homo sapiens
3 The Raman spectra of the DPPC liposome in the C-H symmetric strech vibration lost intensity near 2850cm-1, therefore, it can be predicted that VP16-213 is localized at C1-C9 methylene region of the bilayer, which leads to the increase of the membrane"s regularity and the decrease of its fluidity. 1,2-Dipalmitoylphosphatidylcholine host cell factor C1 Homo sapiens