Protein Name host cell factor C1
Organism Homo sapiens
Gene ID 3054
Gene Symbol


UniProt P51610 (HCFC1_HUMAN), A6NEM2 (A6NEM2_HUMAN)
Relationships Total Number of functionally related compound(s) : 516
Total Number of Articles : 986

host cell factor C1

Gene Summary

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

  • host cell factor 1
  • VP16-accessory protein
  • protein phosphatase 1, regulatory subunit 89
Click to show/hide the synonyms