Pub. Date : 2015
PMID : 26098642
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idiosyncratic lapatinib-induced liver injury has been reported to be associated with human leukocyte antigen (HLA)-DRB1*07:01. | Lapatinib | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 2 | In order to investigate its mechanism, interaction of lapatinib with HLA-DRB1*07:01 and its ligand peptide derived from tetanus toxoid, has been evaluated in vitro. | Lapatinib | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 3 | Here we show that lapatinib enhances binding of the ligand peptide to HLA-DRB1*07:01. | Lapatinib | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 4 | Furthermore in silico molecular dynamics analysis revealed that lapatinib could change the beta chain helix in the HLA-DRB1*07:01 specifically to form a tightly closed binding groove structure and modify a large part of the binding groove. | Lapatinib | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |
| 5 | These results indicate that lapatinib affects the ligand binding to HLA-DRB1*07:01 and idiosyncratic lapatinib-induced liver injury might be triggered by this mechanism. | Lapatinib | major histocompatibility complex, class II, DR beta 1 | Homo sapiens |