Protein Name major histocompatibility complex, class II, DR beta 1
Organism Homo sapiens
Gene ID 3123
Gene Symbol


UniProt P01911 (DRB1_HUMAN), Q5Y7D1 (Q5Y7D1_HUMAN), D7RIH8 (D7RIH8_HUMAN), A0A224MM52 (A0A224MM52_HUMAN), X5DNQ0 (X5DNQ0_HUMAN)
Relationships Total Number of functionally related compound(s) : 402
Total Number of Articles : 829

major histocompatibility complex, class II, DR beta 1

Gene Summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]

  • major histocompatibility complex, class II, DR beta 1 precursor
  • HLA class II histocompatibility antigen, DR-1 beta chain
  • MHC class II HLA-DR beta 1 chain
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