Title : Complement C5a-C5aR interaction enhances MAPK signaling pathway activities to mediate renal injury in trichloroethylene sensitized BALB/c mice.

Pub. Date : 2016 Feb

PMID : 26095957






2 Functional Relationships(s)
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1 TCE sensitization also caused the deposition of major pro-inflammatory cytokines IL-2, TNF-alpha and IFN-gamma in the kidney tissue (P < 0.05); this was accompanied by increased expression of P-p38, P-ERK and P-JNK proteins (P < 0.05). Trichloroethylene interleukin 2 Mus musculus
2 Pretreatment with the C5aR antagonist attenuated the increase of expression of P-p38, P-ERK and P-JNK proteins (P < 0.05) and also consistently reduced the TCE sensitization-induced increase of IL-2, TNF-alpha and IFN-gamma (P < 0.05). Trichloroethylene interleukin 2 Mus musculus