Pub. Date : 2015 Jun 18
PMID : 26084465
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The impact of insulin on chemotherapeutic sensitivity to 5-fluorouracil in gastric cancer cell lines SGC7901, MKN45 and MKN28. | Fluorouracil | insulin | Homo sapiens |
| 2 | This study aimed to explore the impact of insulin on chemoresistance to 5-fluorouracil in gastric cancer and the possible mechanisms. | Fluorouracil | insulin | Homo sapiens |
| 3 | The effect of insulin on chemotherapeutic sensitivity of the three gastric cancer cell lines to 5-fluorouracil was evaluated by pre-incubation with insulin before administration of 5-fluorouracil. | Fluorouracil | insulin | Homo sapiens |
| 4 | The effect of insulin on chemotherapeutic sensitivity of the three gastric cancer cell lines to 5-fluorouracil was evaluated by pre-incubation with insulin before administration of 5-fluorouracil. | Fluorouracil | insulin | Homo sapiens |
| 5 | Addition of 1 muM insulin remarkably promoted the proliferation of SGC7901, MKN45 and MKN28 cells and decreased the cytotoxicity of 5-fluorouracil. | Fluorouracil | insulin | Homo sapiens |
| 6 | CONCLUSION: Insulin improved the proliferation of gastric cancer cell lines and contributed to chemoresistance of gastric cancer cells to 5-fluorouracil which is likely to involve upregulation of P-glycoprotein. | Fluorouracil | insulin | Homo sapiens |