Title : [Effects of metformin on the polarization and Notch 1 expression of RAW264.7 macrophages].

Pub. Date : 2015 Apr 28

PMID : 26081514






2 Functional Relationships(s)
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1 RESULTS: At the concentrations of 0-10 mmol/L for 0-48 h, metformin in concentration and time-dependent ways promoted the expression of IL-10 mRNA and inhibited the mRNA expression of IL-1beta in RAW264.7 macrophages (both P < 0.05). Metformin interleukin 10 Homo sapiens
2 In metformin-treated cells, the expressions of Arg1 (P = 0.009), IL-10 (P = 0.015) and IL-4 (P = 0.001) mRNA increased while the expressions of IL-1beta (P = 0.001) and IL-6 (P = 0.032) mRNA decreased. Metformin interleukin 10 Homo sapiens