Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.

Pub. Date : 2016 Jun

PMID : 26076923






1 Functional Relationships(s)
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1 In vitro incubation study of human liver, intestine and kidney s9 fractions demonstrated that the ACEI prodrugs enalapril, ramipril, perindopril, moexipril and fosinopril are selectively activated by CES1 in the liver. Ramipril carboxylesterase 1 Homo sapiens