Pub. Date : 2015 Jun
PMID : 26062420
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compared with ox-LDL group, testosterone showed stronger inhibitory effect on the proliferation of VSMCs induced by ox-LDL, arrested most of the cells in the G0/G1 phase, ascended significantly the expression levels of Mfn2 and alpha-SMA, and descended significantly the expression levels of p-ERK1/2, PCNA and OPN in the two testosterone groups in a slight dose-dependent manner. | Testosterone | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | CONCLUSION: Testosterone can inhibit phenotypic transition and proliferation of VSMCs induced by ox-LDL in vitro, which may be related to the up-regulated expression of Mfn2 and the suppression on ERK1/2 pathway. | Testosterone | mitogen activated protein kinase 3 | Rattus norvegicus |