Title : Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases.

Pub. Date : 2015 Jul 21

PMID : 26058329






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 N-Substituted conjugates of cyclam and cyclen with bioisosteric phosphonate groups displayed good activities toward T-cell protein tyrosine phosphatase with IC50 values in the micromolar to nanomolar range and showed selectivity over PTP1B, CD45, SHP2, and PTPbeta. Organophosphonates protein tyrosine phosphatase receptor type C Homo sapiens