Protein Name protein tyrosine phosphatase receptor type C
Organism Homo sapiens
Gene ID 5788
Gene Symbol

PTPRC

UniProt P08575 (PTPRC_HUMAN), M9MML4 (M9MML4_HUMAN)
Relationships Total Number of functionally related compound(s) : 520
Total Number of Articles : 702
Description

protein tyrosine phosphatase receptor type C

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

synonyms
  • receptor-type tyrosine-protein phosphatase C
  • CD45 antigen
  • T200 glycoprotein
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Properties