Title : Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.

Pub. Date : 2015

PMID : 26046350






1 Functional Relationships(s)
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1 These three compounds shared a 3-trifluoromethyl-4-methylpiperazinephenyl pharmacophore that stabilizes the "DFG-out" inactive conformation of RET activation loop. 3-trifluoromethyl-4-methylpiperazinephenyl ret proto-oncogene Homo sapiens