Title : Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes.

Pub. Date : 2015 Jul 10

PMID : 26036634






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Lapatinib was shown to increase the accumulation of doxorubicin in ABCB1-overexpressing hepatocellular cancer cells and normal liver tissues without altering the protein level of ABCB1. Lapatinib ATP binding cassette subfamily B member 1 Homo sapiens
2 Our study thus revealed for the first time that the higher incidence of hepatotoxicity during this combinational treatment was due to the increased drug accumulation in hepatocytes mediated by the inhibition of ABCB1 by lapatinib. Lapatinib ATP binding cassette subfamily B member 1 Homo sapiens