Title : Stathmin potentiates vinflunine and inhibits Paclitaxel activity.

Pub. Date : 2015

PMID : 26030092






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In a previous study we showed that stathmin increases vinblastine (VLB) binding to tubulin, and that conversely VLB increases stathmin binding to tubulin. Vinblastine stathmin 1 Homo sapiens
2 Taken together with the previous study using vinblastine, our results suggest that stathmin can be seen as a modulator of MTA activity and binding to tubulin, providing molecular explanation for multiple previous cellular and in vivo studies showing that stathmin expression level affects MTAs efficiency. Vinblastine stathmin 1 Homo sapiens
3 Taken together with the previous study using vinblastine, our results suggest that stathmin can be seen as a modulator of MTA activity and binding to tubulin, providing molecular explanation for multiple previous cellular and in vivo studies showing that stathmin expression level affects MTAs efficiency. Vinblastine stathmin 1 Homo sapiens