Pub. Date : 2015 May 28
PMID : 26025411
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to investigate the effect of a specific MDR1 small interference RNA (siRNA) on sensitivity of oxaliplatin—resistant SW480 human colon cancer cell line (SW480/OxR) to the chemotherapeutic drug oxaliplatin. | Adenosine Monophosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | MDR1 down—regulation synergistically increased the cytotoxic effects of oxaliplatin and spontaneous apoptosis SW480/OxR. | Adenosine Monophosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Our data demonstrates that RNA interference could down regulate MDR1 gene expression and reduce the P—gp level, and partially reverse the drug resistance in SW480/OxR cells in vitro. | Adenosine Monophosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |