Title : Cyclin-dependent kinase 5 regulates the proliferation, motility and invasiveness of lung cancer cells through its effects on cytoskeletal remodeling.

Pub. Date : 2015 Sep

PMID : 26018459






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of CDK5 by roscovitine and small interfering (si)RNA was used to investigate the mechanism of CDK5 in the process of A549 lung cancer cell proliferation, migration and invasion. Roscovitine cyclin dependent kinase 5 Homo sapiens
2 The results demonstrated that functional inhibition of CDK5 using roscovitine and siRNA markedly suppressed the proliferation of A549 cells and resulted in a reduced tumor mass in vivo. Roscovitine cyclin dependent kinase 5 Homo sapiens