Pub. Date : 2015 Sep
PMID : 26018318
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of Twist in the two cell lines markedly increased GDF15 expression, cell invasion, matrix metalloproteinase-2 expression/activity and the half maximal inhibitory concentration (IC50) values of cisplatin, which was eradicated by GDF15 knockdown or the selective p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 (10 microM). | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | In conclusion, the present study, for the first time, to the best of our knowledge, demonstrated that Twist promotes PC cell invasion and cisplatin chemoresistance through inducing GDF15 expression via a p38 MAPK-dependent mechanism. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |