Title : Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas.

Pub. Date : 2015 Jun 30

PMID : 26010414






1 Functional Relationships(s)
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1 CONCLUSIONS: The combination of TH-302, VEGF-A inhibition, and RT is highly effective in preclinical models of sarcoma and is associated with increased DNA damage and apoptosis in endothelial cells and decreased HIF-1alpha activity. TH 302 hypoxia inducible factor 1 subunit alpha Homo sapiens