Title : TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells.

Pub. Date : 2015 Sep

PMID : 26001614






1 Functional Relationships(s)
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1 Co-treatment with mammalian target of rapamycin kinase complex 1 (mTORC1) inhibitor PP242, which activated transcription factor EB (TFEB) signaling and lysosome biogenesis, partially rescued the accumulation of alpha-SYN in PC12 cells and midbrain neurons. PP242 synuclein alpha Homo sapiens