Pub. Date : 2015 May 19
PMID : 25990959
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70. | Tyrosine | zeta chain of T cell receptor associated protein kinase 70 | Homo sapiens |
2 | The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70. | Tyrosine | zeta chain of T cell receptor associated protein kinase 70 | Homo sapiens |
3 | This model incorporated negative feedback regulation of Lck activity by the kinase activity of ZAP-70 and predicted the order in which tyrosines in the ITAMs of TCR zeta chains must be phosphorylated to be consistent with the experimental data. | Tyrosine | zeta chain of T cell receptor associated protein kinase 70 | Homo sapiens |