Protein Name zeta chain of T cell receptor associated protein kinase 70
Organism Homo sapiens
Gene ID 7535
Gene Symbol


UniProt P43403 (ZAP70_HUMAN)
Relationships Total Number of functionally related compound(s) : 170
Total Number of Articles : 336

zeta chain of T cell receptor associated protein kinase 70

Gene Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • tyrosine-protein kinase ZAP-70
  • 70 kDa zeta-associated protein
  • 70 kDa zeta-chain associated protein
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