Title : Association of fludarabine pharmacokinetic/dynamic biomarkers with donor chimerism in nonmyeloablative HCT recipients.

Pub. Date : 2015 Jul

PMID : 25983023






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fludarabine"s metabolite, 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A), undergoes cellular uptake and activation to form the active cytotoxic metabolite fludarabine triphosphate (F-ara-ATP), which inhibits cellular DNA synthesis in CD4(+) and CD8(+) cells. fludarabine CD4 molecule Homo sapiens
2 Fludarabine"s metabolite, 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A), undergoes cellular uptake and activation to form the active cytotoxic metabolite fludarabine triphosphate (F-ara-ATP), which inhibits cellular DNA synthesis in CD4(+) and CD8(+) cells. fludarabine CD4 molecule Homo sapiens
3 Fludarabine"s metabolite, 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A), undergoes cellular uptake and activation to form the active cytotoxic metabolite fludarabine triphosphate (F-ara-ATP), which inhibits cellular DNA synthesis in CD4(+) and CD8(+) cells. fludarabine CD4 molecule Homo sapiens