Pub. Date : 2015 Jun
PMID : 25982794
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that CBG caused the significant activation of ERK, JNK and p38 MAPK in U266 cells. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Taken together, these findings suggest that CBG can act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells. | cinobufagin | mitogen-activated protein kinase 1 | Homo sapiens |