Title : Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.

Pub. Date : 2015 May 20

PMID : 25980580






1 Functional Relationships(s)
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1 To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background. Histidine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens