Pub. Date : 2015 May 20
PMID : 25980580
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background. | Histidine | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |