Pub. Date : 2015 Jul 3
PMID : 25975270
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD). | Dioxins | aryl-hydrocarbon receptor | Mus musculus |
| 2 | The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD). | Dioxins | aryl-hydrocarbon receptor | Mus musculus |
| 3 | Here, we show that the loss of TCDD-inducible poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality. | Dioxins | aryl-hydrocarbon receptor | Mus musculus |
| 4 | These results reveal previously unidentified roles for Tiparp, MacroD1, and ADP-ribosylation in AHR-mediated steatohepatitis and lethality in response to dioxin. | Dioxins | aryl-hydrocarbon receptor | Mus musculus |